Potassium, ministeriali diuretic. Is a competitive antagonist of aldosterone on the effect on the distal nephron (competes for binding to cytoplasmic protein receptors, decreases the synthesis permeaz in aldosterone-dependent plot of the collecting tubes and distal tubules), increases excretion of Na+, Cl – and water, reduces excretion of K+ and urea, reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect which is not constant. The hypotensive effect is not dependent on the level of renin in blood plasma and does not occur with normal blood pressure.
The diuretic effect is manifested on day 2-5 of treatment.
Inside. Adults with primary hyperaldosteronism in the period of preparation for the operation — 100-400 mg per day, if no treatment is chosen the minimum effective dose; for edema (cardiac, hepatic and renal origin) in the initial dose — 100 mg per day in divided doses, 5 days, depending on clinical effect, reduce the dose to 25 mg or increased to 200 mg; hypertension in an initial dose of 50-100 mg per day in divided doses, after 2 weeks it is possible to increase or reduce the dose (depending on effect); if hypokalemia caused by diuretics 25-100 mg per day.
Active chemical substance: spironolactone.
Aldactone (Spironolactone) belongs to the subgroup of potassium-sparing diuretics. Works on the hormone aldosterone, which regulates water balance in the organism, accelerates the excretion of potassium and prevents excessive excretion of sodium and water. The higher the aldosterone level, the more water accumulates in the body. Spironolactone is an aldosterone antagonist, its use allows to reduce the level of aldosterone in the body and thus to increase the excretion of sodium and water, which simultaneously leads to an accumulation of Cali. Using spironolactone (for us it is often sold under the name “Verospiron”) of potassium in the body do not accumulate. Like other dioretikam, it also removes potassium from the body. Just in smaller quantities. Therefore, it is called kaliysberegayuschimi diuretic. A small loss of potassium is, but it is relatively easy for kompensiruet sravneniu stop the loss of potassium that we saw, say, tiazidove diuretics. Therefore, the aldactone along with the similar current Triamterenom (Dyrenium) and Amiloride (Midamor) constitute a group of potassium-sparing diuretics, which act on the body is much “softer” than other groups of diuretics – thiazides and “loop agents” (saluretics).
What should pay attention to the departures taking Aldactone (Spironolactone) (or other potassium-sparing diuretics) is that in parallel you cannot take chemical drugs potassium, because this can lead to life-threatening increase of level of potassium in the body.
It should be noted that Aldactone has anti-androgenic qualities, as a result lowers the level of androgens in the blood. The bodybuilders use this property of Aldactone in order to minimize the phenomenon of masculinization when steroid “course”, and also for the return of femininity after them. Men have another problem: since changing the ratio of androgens-estrogens in favor of poslanih, often accompanying the reception of Aldactone phenomena in men are the painful swelling of the nipples up to gynecomastia.
Other possible accompanying taking Aldactone (Spironolactone) negative effects: low blood pressure, cramps in the muscles, dizziness, gastrointestinal disorder, vomiting, irregular heartbeat, weakness. However, side effects of potassium-sparing diuretics compared with the thiazide-and “loop agents” are much less.
Since taking Aldactone (Spironolactone) does not instantly manifesting a strong effect of dehydration, athletes start taking it 1-2 weeks before the competition. The most common dosage is 50 mg per day.