Modafinil

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The new generation of stimulant Modafinil ((±) -2- (benzhydrylsulfinyl) acetamide), other commercial names (Modafinil, Provigil, Alertec, Modavigil, Modalert, Modiodal, Modafinilo, Carim, Vigia) is a drug derived from a substance called Adrafinil ) developed in 1970 by the French company Lafon Laboratories.

The drug belongs to the class of nootropics. Nootropics, they are neurometabolic stimulants are the means that exert a direct activating influence on learning, improving memory and mental activity, and also increasing the resistance of the brain to aggressive influences.

The term “nootropic” is composed of Greek. – mind and – turn, stir, change. It was introduced in 1972 to describe the effects on the sensitively-cognitive sphere of the effects of pyracetam Modafinil, like other stimulants, increases the release of monoamines, in particular, the catecholamines norepinephrine and dopamine from the synaptic terminals.

Nevertheless, Modafinil also increases the level of histamine in the hypatalamus, as a result of which some researchers consider Modafinil to be a “wakeful agent” rather than a classic amphetamine. However, despite the histaminergic action of Modafinil, it partly refers to the amphetamine class of stimulants because of its effect on the level of norepinephrine and dopamine.
The American Federal Service for the Control of Quality of Food and Drug Administration has classified Provigil as the most effective means to combat narcolepsy.

ModafinilNarcolepsy (from Greek-Greek numbness, sleep and attack, synonyms: narcoleptic disease, Gelino’s disease, essential narcolepsy) – a disease of the nervous system related to hypersomnia, characterized by daytime bouts of insuperable drowsiness and attacks of sudden falling asleep, attacks of cataplexy, that is, sudden loss of muscle tone with clear consciousness, disturbed sleep at night, the appearance of hypnagogic (when falling asleep) and hypnapopic (on awakening) hallucinations. Sometimes there is a brief paralysis of the body (the inability to move arms and legs) immediately after awakening.)
Areas of use. In addition to narcolepsy, Modafinil is also used effectively in attention deficit disorder, in the treatment of resistant depression and multiple sclerosis, and is used as an additional agent in the treatment of antidepressants.

Because of the ability to significantly increase the endurance of the body and effects similar to that of amphetamine and the increase in the number of athletes caught using MODAFINIL in international competitions, the World Anti-Doping Agency introduced Modafinil to the list of prohibited preparations in the sport and recognized the medicinal remedy Provigil t. e. Modafinil is a doping agent. In this regard, Modafinil quickly began to gain popularity among the environment, drivers, programmers of amateur athletes, shift workers. The drug is also used in the treatment of fibromyalgia, chronic fatigue syndrome, myotonic dystrophy, spastic cerebral palsy and Parkinson’s disease. In recent years, Modafinil is often used as a highly effective agent for reducing appetite and weight loss. Studies have shown that when Modafinil is used, the overall appetite level of the subjects is reduced by at least 38%, which in turn leads to rapid weight loss. Today, scientists are considering the possibility of using Modafinil in the treatment of cocaine dependence, primary biliary cirrhosis and bipolar disorder. The facts of misuse and abuse of Modafinil by students in the UK and France, club youth and entertainment workers have been documented, which led to fierce disputes about the safety of Modafinil and its legal status, but except for the USA where Modafinil is a controlled substance and is on the list of medicines No. 4 neither one of the countries of the world Modafinil is not a drug and absolutely legal.

Military departments of some countries of the world plan to replace the traditional amphetamine in the first-aid kits of special forces fighters at Modafinil in connection with its more effective and favorable impact on the human body. Modafinil has already been successfully used by cosmonauts, military and emergency personnel in several European countries.
Modafinil helps a lot of people in situations where it is necessary to be in the best shape and perfect tone to use all their potential to achieve their goals. It is a powerful stimulant that improves memory, intellectual acuity and other parameters of mental activity. It effectively relieves fatigue and restores cognitive functions of the brain. Modafinil is one of the best tools for stimulating mental activity, reducing the need for sleep and treating depression. A very important positive point is the absence of such side effects as: addiction, overexcitation and a decrease in the sense of responsibility Modafinil as a drug occurs in the form of tablets and powder. and at reception it is necessary to consider that in tablets besides Modafinilum contains some quantity of auxiliary substances while in the form of a powder Modafinil is issued in the pure state that accordingly influences pharmacologically active dosage of a preparation. Usually, the prescribed dose is 200 mg once a day (less often, 100 to 400 mg / day in one or two doses). Modafinil, as a rule, is taken in one dose in the morning or in two doses in the morning and at noon. As a rule, it is not recommended to take modafinil after noon: modafinil is a drug with a long half-life and withdrawal from the body can take up to 15 hours, and its reception after noon carries the risk of sleep disorders.

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