Azithromycin is a broad-spectrum antibiotic, the first member of a new subgroup of macrolide antibiotics called azalides. The molecule is designed by adding an oxygen atom to the lactone ring of erythromycin A. Azithromycin The chemical name is 9-deoxy-9a-aza-9a-methyl-9a -gomoeritromitsi A. Molekrulyarny weight is 749.0.
The mechanism of action of azithromycin – binding to 50 S unit of the ribosome, which prevents the synthesis and translocation of proteins of bactericidal peptides.
Azithromycin seldom causes side reactions.
The table shows adverse effects on disease manifestations and frequency. Side effects classified by frequency as follows: very often (≥ 1/10); often (≥ 1/100 to <1/10); infrequently (≥ 1 / 1,000 to <1/100); rare (≥ 1 / 10,000 to <1/1 000);very rare (<1/1 0000), unknown (can not be estimated from the available data).Side effects in each group in terms of frequency are indicated on a scale from more frequent to less frequent.
Adults with infections of the upper and lower respiratory tract, skin and soft tissue infections assigned to 0.5 grams per day 1, followed by 0.25 g of the 2nd to 5th day or 0.5 g daily for 3 days (a course dose 1.5 g).
In acute infections of the urogenital (genitourinary) tract designate single 1 g (2 tablets of 0.5 g).
When Lyme disease (borreliosis) for the treatment of the first stage (erythemamigrans) appoint 1 g (2 tablets of 0.5 g) in 1-day and to 0.5 g daily from the 2nd to 5th day (course dose 3 g).
Children prescribed medication based on body weight. Children weighing more than 10 kg from the calculation: a s 1 day – 10 mg / kg body weight; over the next 4 days – 5 mg / kg. Chance of a 3-day course of treatment; In this case, a single dose of 10 mg / kg. (Course dose 30 mg / kg body weight).
Recommended break in 2 hours between the reception of azithromycin and antacid (lowering gastric acidity) drugs for their simultaneous assignment.