After oral administration, placealon is quickly and almost completely absorbed in a wide range of doses from 25 to 100 mg. The maximum levels of the drug in the serum are 3.1 + 1.1 ng / ml after 1.6 + 0.6 hours. Then the level of the drug in the serum decreases with a terminal half-life of 12-13 hours. 98% of the siteolon binds to serum proteins. The binding with albumin is 40%, while binding to GSH (globulin binding sex steroids) is 58%.
Mesterolone is rapidly metabolized. The metabolic clearance in serum is 4.4 + 1.6 ml · min -1 · kg -1 . The drug is not excreted by the kidneys in an unchanged state. The main metabolite is 1α-methyl-androsterone, the conjugated form of which is 55-70% of metabolites excreted by the kidneys. The ratio of the main metabolite of glucuronide to its sulfate is about 12: 1. Another metabolite constituting about 3% of the metabolites excreted by the kidneys is 1α-methyl-5α-androstan-3α, 17β-diol. Metabolic conversion to estrogens or corticosteroids does not occur.
Effects of taking Provirona
- Some anabolism.
- Strengthening the relief and hardness of muscle fibers. Thanks to this effect, the steroid is so popular in bodybuilding. Provironum is often used by athletes in dosages close to the minimum.
- Improve the quality and quantity of spermatozoa.
- Stimulation of development of male genital organs and secondary sexual characteristics.
- Strengthening of sexual desire and improvement of potency on the course.
How to take Provironum
The course of Provironum often involves compensating for side effects that can be caused by the ingestion of other anabolic and androgenic steroids. And to be more precise, it can be argued about the advisability of using the drug to eliminate such estrogenic manifestations, such as, for example, a decrease in libido. The daily recommended dosage ranges from 50 to 150 milligrams and is determined in accordance with the experience of the athlete in the application of sports pharmacology, the severity of the course and its ultimate goal, as well as some individual physiological indicators.
As for how to take Provironum from Bayer to women, then it is not recommended for women to use it, because androgenic activity is too high. Although, there are some opinions on the high effectiveness of the combination of a steroid with Tamoxifen for fat burning. The course of the drug should be started only after consulting a specialist and taking the tests. It is not recommended to take a steroid to underage athletes, and also to those who have any contraindications or individual intolerance to the active substance.
The similarity of the placeolone to dihydrotestosterone, as well as its chemical nature, can cause such side effects from Provironum as prostatic hypertrophy and alopecia. In the most severe cases, development of benign and malignant liver tumors is possible. To prevent adverse reactions it is recommended to conduct periodic examination of the prostate. An inappropriate tightening of the Provironum course, accompanied by high doses of the steroid, can cause an increase in liver size, pain in the upper abdomen and intra-abdominal hemorrhage.